1252 Interferon mediated resistance of melanoma cells to oncolytic viruses is regulated by the melanocyte lineage transcription factor MITF

Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.

Perhaps the most obvious manifestation of the complex interplay between environmental cues, signal transduction pathways, and transcription factors underlying the genesis and differentiation of a cell lineage is provided by the enormous diversity of genetically determined pigmentation patterns. Because melanocytes, the cells responsible for skin, hair, and eye color, are dispensable for viabili...

Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and which exhibited phenotypic synergy with Mitf in mice. BCL2's regulation by Mitf...

Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma

BACKGROUND Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient efficacy. Thus, identification of new melanocyte/melanoma antigens that serve as potential novel candidate biomarkers in melanoma is an important area for investigation. METHO...

Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements.

Manipulation of gene expression in melanocytes is an important tool for studying pigment cell biology. We constructed transgenic mice in which Cre recombinase was placed under the control of regulatory elements from the Microphthalmia-associated transcriptional factor (Mitf) gene using bacterial artificial chromosome (BAC). Bacterial artificial chromosome that contained either 50 or 108 kb DNA ...

The Microphthalmia-associated Transcription Factor (mitf) Requires Swi/snf Enzymes to Activate Melanocyte Specific Genes